Intensify Research on the Major Drivers of Childhood Cancers
Chromosomes can rearrange themselves, leading to the formation of fusion oncoproteins. These abnormal fusion proteins are drivers of cancer, particularly childhood cancers. There are few cancer therapies that target the type of target fusion oncoproteins that are most common in children. A greater understanding of these fusion oncoproteins is needed to make progress in pediatric cancer research and develop new treatments for childhood cancers.
The goal of this recommendation is to develop a coordinated research effort that will help improve the understanding of these fusion oncoproteins that drive selected cancers. Using a collaborative approach, this initiative aims to learn more about how fusion oncoprotein-driven cancers develop, create experimental models, and identify key dependencies of fusion oncoproteins.